Yeah it is really happening it seems, really looking forward to some videos of hard and software in action. 
If anyone can get access to (even unfinished) designs of V9978 and R800 and improve upon them in FPGA it’s Nishi. Don’t say it’s not possible, relations with Yamaha were pretty tight and R800 was an ASCII design (surely with help of Zilog). Still we have to remain realistic and it may be something different (there are too little facts at the moment).
In his Twitter spaghetti response Mr. Nishi confirms somewhere that it will look similar to raspberry Pi 400.
But somewhere else he stated that he is working on a notebook. Maybe he’s still not sure how the end product will look like
Or there will be multiple options 
Or just a translation error..
Anything that's not going to be backwards compatible with MSX (and no, I don't count software emulation as compatible), should not be considered an MSX imho. 
So PCs are no longer PCs, Mac computers are no longer Mac, and so on...
You can't run a dos game on a modern pc without emulation (and probably there are plenty PCs that doesn't have BIOS to run even disk access in real mode). That's life, sure enough any real try of rebooting a MSX with modern features will use emulation for backwards compatibility.
The difference imho is that MSX was always designed to be a standard with compatibility in mind, including backwards compatibility.
The Intel Macs (and now M1 I guess? Haven't really been keeping up with them anymore) weren't designed to be backwards compatible as such with their PowerPC predecessors. As for PC games, I think the issue is more that MS-DOS has been left along the roadside, making it more of a software than a hardware compatibility issue.
And indeed, as LGR demonstrates with his video of running DOS on a Rizen PC, games will actually still run on modern systems without emulation. Sure, there are some compatibility issues such as colours being a bit off, and some 3D instruction sets glitching out, and you might need FreeDOS rather than MS-DOS to get some of the modern hardware such as USB drives accessible, but overall the hardware is still capable of running DOS games without emulation.
