The F4 port is not required, but very much desired on MSX2+. Usually making this port when converting MSX2 computers to MSX2+ requires heavy rewiring of system's logic and adding new components on top of existing ones. It appears that Kamil Karimov (a.k.a Caro) has designed a simple board that could add F4 register to MSX2+ without major hassle. All you need is to solder 4 microchips in SOP form factor and a few SMD components on a small board and then connect this board to Z80's outputs. Below is the schematics and the board's picture.
As you might see, the board has the same size and form factor as Z80 chip, so technically it can be soldered on top of the processor. Not very complicated for a skilled person who decided to upgrade his MSX2 to MSX2+.
Please note that I have not tested this board myself yet, but so far everything that Kamil has been creating worked for me. The guy is a genius! So if someone wants to purchase this board for a very small fee, please send me an e-mail. Only 8 boards are available. I may be able to assemble a couple of boards from the components I have, but the price will be, of course, different.
Alexey