It's an interesting concept.
the guy is a fan of the nes and is producing the entire thing alone,
and it will arrive for wii/ps3/360 and vita.
the msx has enough game reference to use in a game like this, but for the msx platform.
Brian Provinciano spent many years on this project. It started as an ambitious NES project called Grandtheftendo, but then he moved to current platforms.
Yes it could be possible on MSX2(or up)
No, it will never happen, unless you learn how to code and do it yourself.